From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity
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منابع مشابه
Responses of Muscle Mitochondrial Function to Physical Activity: A Literature Review
Skeletal muscles play an active role in regulating the metabolic homeostasis through their ability for relating to adipose tissue and endocrine hormones. Contraction of the skeletal muscle leads to increased release of several myokines, such as irisin, which is able to interact with the adipose tissue. Physical activity promotes the irisin mechanism by augmenting the peroxisomes (PGC1-α) in the...
متن کاملEffect of 12-Week Pilates training on Plasma Levels of PGC1-α and Irisin in Obese Women
Abstract Background & Purpose: Obesity is the most common metabolic disorder and important problem of the last decade. Exercise activity can reduce the negative effects of obesity by affecting PGC-1α and subsequent increases in Irisin, it can change the white adipose tissue and convert it into brown adipose tissue. The purpose of this study was to investigate the effect of 12 weeks Pilates tra...
متن کاملمعرفی هورمون ورزش (Irisin)
Introduction: Almost 15% of world populations suffer from obesity. Obesity and insulin resistance are the key pathogenesis risk factors of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Exercise training can accelerate metabolism and help to prevent the obesity and diabetes through induction of Irisin and triggers conversion of white adipose tissue to brown adipose tissue. Metho...
متن کاملSwimming intervention mitigates HFD-induced obesity of rats through PGC-1α-irisin pathway.
OBJECTIVE Irisin, a newly discovered myokine, can drive the browning of white adipocytes to control body weight or mitigate obesity progression through regulating energy metabolism. However, the underlying mechanisms or specific signal pathways of exercise-induced irisin on the management of obesity are still unclear. MATERIALS AND METHODS Totally 30 rats were subjected to high fat diet (HFD)...
متن کاملThe structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation.
Irisin was recently identified as a putative myokine that is induced by exercise. Studies suggest that it is produced by cleavage of the FNDC5 (fibronectin domain-containing protein 5) receptor; irisin corresponds to the extracellular receptor ectodomain. Data suggesting that irisin stimulates white-to-brown fat conversion have led to the hypothesis that it does so by binding an unknown recepto...
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